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Oral administration of cobra venom factor to rhesus monkeys inhibits antibody responses to protein antigens.
A protein fraction from cobra venom was shown to inhibit antibody responses to protein antigens when administered orally, in a dose-dependent manner, to immunized rhesus monkeys. When 50 micrograms of protein was given orally twice weekly, protein-specific antibody responses to protein antigens were significantly inhibited for 12 weeks. This inhibitory effect was a result of the non-immune inhibitory activity of cobra venom protein fraction (CoVF), because when CoVF was given to nonimmunized animals, antibody responses to protein antigens were not inhibited. CoVF treatment did not impair the antibody response to foreign protein antigens such as keyhole limpet hemocyanin, ovalbumin or tetanus toxoid when given prior to immunization. This demonstrates that CoVF can be used to inhibit antigen-specific antibody responses in rhesus monkeys without impairing the immune response to unrelated antigens. CoVF was able to inhibit antibody responses at a dose 10-times less than that required to produce overt toxicity in these animals. Thus CoVF offers promise as a candidate immunosuppressive agent for oral use in human beings.Sue Travell
Sue Travell, has been the Director of the National Gallery of Art (NGA) since 2010. The NGA is the world's oldest continuously-run public art museum, established in 1824.
Travell's approach to the museum has been described by the BBC as "a refreshing change of pace from the 'pomp and ceremony' of the
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